科研成果
发表论文:
# (co-first author), * (corresponding author)
20. Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351.
19. Bin Tan#, Liping Zhang#, Qingbo Zhang#, Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27): e202302043.
18. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang,* Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979-985.
17. Ziqian Cheng,# Qingbo Zhang,# Jing Peng,# Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven discovery of benzoxazole alkaloids from the marine-derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821.
16. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, (12): 1478–1484.
15. Bin Tan, Qingbo Zhang,* Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84.
14. Bin Tan, Qingbo Zhang,* Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103.
13. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal macrolides kongjuemycins from coral-associated rare actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487.
12. Xiaodong Jiang,# Zhuangjie Fang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021,19 (19): 4243-4247.
11. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194.
10. Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069.
9. Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130.
8. Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773.
7. Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang and Changsheng Zhang*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066.
6. Ruidong Chen,# Qingbo Zhang,# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700.
5. Qingbo Zhang,# Huixian Li,# Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, ShuMing Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu,* and Changsheng Zhang*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077.
4. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36.
3. Qingbo Zhang,# Huixian Li,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145.
2. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,* Changsheng Zhang*. N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012 (27): 5256-5262.
1. Huixian Li,# Qingbo Zhang,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005.
发表著作
(1)Assembly line and post-PKS modifications in the biosynthesis of marine polyketide natural products. Book chapter in: Comprehensive Natural Products III: Chemistry and Biology. Elsevier,2020-01,第2作者。